Osteomyelitis Unraveling Different Genre of Osteopetrosis: A Case Series
Akanksha Bhardwaj *
GDC&H, Chhatrapati Sambhajinagar, Maharashtra, India.
M S Mandale
GDC&H, Chhatrapati Sambhajinagar, Maharashtra, India.
Jayanti Humbe
GDC&H, Chhatrapati Sambhajinagar, Maharashtra, India.
Vaishali Nandkhedkar
GDC&H, Chhatrapati Sambhajinagar, Maharashtra, India.
Savita Wagh
GDC&H, Chhatrapati Sambhajinagar, Maharashtra, India.
*Author to whom correspondence should be addressed.
Abstract
Osteopetrosis is a rare inherited genetic disease. Three distinct forms of the disease have been recognized, of which autosomal dominant Osteopetrosis is the most common. Malfunctioning of osteoclastic activity and regular osteoblastic activity causes defective bone remodelling, which hampers the bone turnover rate. This increased formation of immature bone can lead to abnormal thickening of cortical bones, which causes narrowing and obliteration of medullary cavities. Patients with osteopetrosis can show following characteristic features: fragility of bones predisposing it to fracture, osteomyelitis, hematopoietic insufficiency, growth impairment, disturbed tooth eruption cranial nerve palsies. This paper report a case series of osteomyelitis which unmasked the presence of osteopetrosis in the patient.
Here, we report two cases of chronic osteomyelitis of the mandible leading to a diagnosis of Osteopetrosis.
Keywords: Marble bone disease, Albers-Schonberg disease, malignant infantile osteopetrosis, Osteomyelitis
How to Cite
Downloads
References
Kant P, Sharda N, Bhowate RR. Clinical and radiological findings of autosomal dominant osteopetrosis type II: A case report. Case Reports in Dentistry. 2013 Oct 24;2013.
Loría-Cortés R, Quesada-Calvo E, Cordero-Chaverri C. Osteopetrosis in children: A report of 26 cases. The Journal of pediatrics. 1977 Jul 1;91(1):43-7.
Wu CC, Econs MJ, DiMeglio LA, Insogna KL, Levine MA, Orchard PJ, Miller WP, Petryk A, Rush ET, Shoback DM, Ward LM. Diagnosis and management of osteopetrosis: Consensus guidelines from the osteopetrosis working group. The Journal of Clinical Endocrinology & Metabolism. 2017 Sep 1;102(9):3111-23.
Okawa R, Yokota Y, Morita Y, Mikasa Y, Nakano K. Osteomyelitis Possibly Caused by Exfoliation of Primary Teeth in a Patient with Osteopetrosis. Children. 2022 Dec 2;9(12):1894.
Mikami T, Miake Y, Bologna-Molina R, Takeda Y. Ultrastructural analyses of alveolar bone in a patient with osteomyelitis secondary to osteopetrosis: A review of the literature. Journal of Oral and Maxillofacial Surgery. 2016 Aug 1;74(8):1584-95.
Del Fattore A, Cappariello A, Teti A. Genetics, pathogenesis and complications of osteopetrosis. Bone. 2008 Jan 1;42(1):19-29.
De Oliveira HD, Pereira Filho VA, Gabrielli MF, Gabrielli MA, Vieira EH. Marginal resection for treatment of mandibular osteomyelitis associated with osteopetrosis: Case report. Journal of Cranio-Maxillofacial Surgery. 2011 Oct 1;39(7):525-9.
Balan A, Girija KL, Ranimol P. Osteomyelitis of maxilla in infantile osteopetrosis: A case report with review of literature. International Journal of Clinical Pediatric Dentistry. 2011 May;4(2): 125.
Krithika C, Neelakandan RS, Sivapathasundaram B, Koteeswaran D, Rajaram PC, Shetkar GS. Osteopetrosis-associated osteomyelitis of the jaws: A report of 4 cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2009 Sep 1;108(3):e56-65.
Junquera L, Rodríguez-Recio C, Villarreal P, García-Consuegra L. Autosomal dominant osteopetrosis and maxillomandibular osteomyelitis. American journal of otolaryngology. 2005 Jul 1;26(4):275-8.
Venkateshwar V, Vaidya A, Roy P, Sampat S, De JK. Osteopetrosis. Medical Journal Armed Forces India. 2003 Oct 1;59(4): 344-6.
Beighton P, Hamersma H, Cremin B. Osteopetrosis in South Africa-the benign, lethal and intermediate forms. South African Medical Journal. 1979 Apr 1;55(17):659-65.
Ishaque A, Farid E, Nasir S, Qadar LT, Jamal A. Intermediate Autosomal Recessive Osteopetrosis With an Unusual Absence of Fractures. Ochsner Journal. 2022 Dec 21;22(4):366-71.