A Case Report on Peripheral Giant Cell Granuloma of Gingiva
Published: 2024-05-02
Page: 39-43
Issue: 2024 - Volume 7 [Issue 1]
Ankita Sharma *
K.D Dental College and Hospital Mathura, Uttar Pradesh, India.
Shailendra S. Chauhan
K.D Dental College and Hospital Mathura, Uttar Pradesh, India.
Radha Kumari
K.D Dental College and Hospital Mathura, Uttar Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
The most prevalent giant cell lesion in the mouth is called a peripheral giant cell granuloma, also referred to as "giant cell epulis." Typically, it manifests as a soft tissue purplish-red nodule with extravasated red blood cells and mononuclear stromal cells surrounding the multinucleated large cells. It is unlikely that this lesion is a real tumor; instead, it may be reactive in character, thought to be triggered by trauma or local irritation, however the exact etiology is unknown. This article describes a 60-year-old female patient who had a peripheral giant cell granuloma that originated in the maxillary anterior area. The lesion was entirely removed down to the periosteum, and the biopsy site shows no signs of ongoing or lingering swelling or bone defects after a follow-up period of 12 months.
Keywords: Giant cell granuloma, peripheral, maxillary anterior, osteoclastic activity
How to Cite
References
Bonetti F, Pelosi G, Martignoni G, Mombello A, Zamboni G, Pea M. Peripheral giant cell granuloma: Evidence for osteoclastic differentiation. Oral Surg Oral Med Oral Pathol. 1990;70:471–5.
Lim L, Gibbins JR. Immunohistochemical and structural evidence of a modified microvasculature in the giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol. 1995;79:190–8.
Mighell AJ, Robinson PA, Hume WJ. PCNA and Ki-67 immunoreactivity in multinucleated cells of giant cell fibroma and peripheral giant cell granuloma. J Oral Pathol Med. 1996;25:193–9.
Souza PE, Mesquita RA, Gomez RS. Evaluation of p53, PCNA, Ki-67, MDM2 and AgNOR in oral peripheral and central giant cell lesions. Oral Dis. 2000;6:35–9.
Bo Liu, Shi-Feng Yu, Tie-Jun Li. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J Oral Pathol Med. 2003;32:367.
Carvalho YR, Loyola AM, Gomez RS, Araujo VC. Peripheral giant cell granuloma. An immuno-histochemical and ultrastructural study. Oral Dis. 1995;1:20–5.
Katsikeris N, Kakarantza-Angelopoulou E, Angelopoulos AP. Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases. Int J Oral Maxillofac Surg. 1988;17:94–9.
Giansanti JS, Waldron CA. Peripheral giant cell granuloma: review of 720 cases. J Oral Surg. 1969;27:787–91.
Hirshberg A, Kozlovsky A, Schwartz-Arad D, Mardinger O, Kaplan I. Peripheral giant cell granuloma associated with dental implants. J periodontol. 2003;74:1 381–4.
Dayan D, Buchner A, Spirer S. Bone formation in peripheral giant cell granuloma. J Periodontol. 1990;61:444–6.
Smith BR, Fowler CB, Svane TJ. Primary hyperparathyroidism presenting as a “peripheral” giant cell granuloma. J Oral Maxillofac Surg. 1988;46:65–9.
Burkes EJ, White RP. A peripheral giant-cell granuloma manifestation of primary hyperparathyroidism: report of case. J Am Dent Assoc. 1989;118:62–4.
Odell EW, Morgan PR. Biopsy pathology of the oral tissues. London: Chapman Hall Medical; 1998;111.
Flanagan AM, Tinkler SMB, Horton MA, Williams MD, Chambers DJ. The multinucleated giant cell granulomas of the jaws are osteoclasts. Cancer. 1988;62:1139–45.
Bischof M, Nedir R, Lombardi T. Peripheral giant cell granuloma associated with a dental implant. International Journal of Oral and Maxillofacial Implants. 2004;19(2):295-302.
El-Mofty SK, Osdoby P. Growth behaviour and lineage of isolated and cultured cells derived from giant cell granuloma of the mandible. J Oral Pathol. 1985;14:539–52.
Cohen MA, Grossman ES, Thompson SH. Features of central giant cell granuloma of the jaws xenografted in nude mice. Oral Surg Oral Med Oral Pathol. 1988;66:209.
Willing M, Engels C, Jesse N, Werner M, Delling G, Kaiser E. The nature of giant cell tumor of bone. J Cancer Res Clin Oncol. 2001;127:467–74.
Abe E, Mocharla H, Yamate T, Taguchi Y. Monolages SC.Meltrinalpha, a fusion protein involved in multinucleated giant cell and osteoclast formation. Calcif Tissue. 1999;64:508–15.
Padam Narayan Tandon, S K Gupta, Durga Shanker Gupta, Sunit Kumar Jurel, Abhishek Saraswat. Peripheral giant cell granuloma, 2012 Apr;3(Suppl 1):S118-21. DOI: 10.4103/0976-237X.95121.