International Journal of Research and Reports in Dentistry

The most prevalent giant cell lesion in the mouth is called a peripheral giant cell granuloma, also referred to as "giant cell epulis." Typically, it manifests as a soft tissue purplish-red nodule with extravasated red blood cells and mononuclear stromal cells surrounding the multinucleated large cells. It is unlikely that this lesion is a real tumor; instead, it may be reactive in character, thought to be triggered by trauma or local irritation, however the exact etiology is unknown. This article describes a 60-year-old female patient who had a peripheral giant cell granuloma that originated in the maxillary anterior area. The lesion was entirely removed down to the periosteum, and the biopsy site shows no signs of ongoing or lingering swelling or bone defects after a follow-up period of 12 months.