International Journal of Research and Reports in Dentistry

Erythema multiforme (EM) is an acute self-limiting hypersensitive mucocutaneous lesion with varied etiologies. It is classified as a spectrum of disorders with Erythema multiforme minor, Erythema multiforme major. Herpes virus infection is considered to be involved in more than 90% of cases. Drug-associated EM is rare and reported to be less than 10%. EM affects most commonly teenagers and young adults with more predilection to males. Oral lesions are seen on the lips and buccal mucosa which appear as erythematous macules, and bloody encrustations involving lips with classic target-like lesions. Here is a case report of erythema multiforme major which was induced by naturopathic medications in a middle-aged woman who presented with classic target lesions and was effectively treated with systemic corticosteroids which showed complete remission and no recurrence had been noted to date.